Folinic acid

CLINICAL USE

Folinic acid rescue Enhancement of 5-fluorouracil cytotoxicity in advanced colorectal cancerFolate deficiency

DOSE IN NORMAL RENAL FUNCTION

Varies according to indication

PHARMACOKINETICS

Molecular weight :511.5

%Protein binding :54

%Excreted unchanged in urine : 80–90 (as inactive metabolites)

Volume of distribution (L/kg) :17.5

half-life – normal/ESRD (hrs) :32–35 minutes/–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Some removal likely. Dose as in normal renal function

HD :Some removal likely. Dose as in normal renal function

HDF/high flux :Dialysed. Dose as in normal renal function

CAV/VVHD :Some removal likely. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsShould not be administered simultaneously with a folic acid antagonist as this may nullify the effect of the antagonist

ADMINISTRATION

Reconstition

For

IV infusion

, compatible with: sodium chloride 0.9%, glucose 5%, sodium lactate injection

Route

IM, IV injection,

IV infusion

, oral

Rate of Administration

Because of the calcium content of leucovorin solutions, no more than 160 mg/minute should be injected IV

Comments

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

Home